The frequency of mammary neoplasia in different species varies tremendously. The dog is by far the most frequently affected domestic species, with a prevalence ~3 times that in women; ~50% of all tumors in the bitch are mammary tumors... About 45% of mammary tumors are malignant in dogs, whereas ~90% are malignant in cats, and dogs have a much higher number of complex and mixed tumors than do cats...
...Mammary tumors in dogs are most frequent in intact bitches; they are extremely rare in male dogs. Ovariectomy before the first estrus reduces the risk of mammary neoplasia to 0.5% of the risk in intact bitches; ovariectomy after 1 estrus reduces the risk to 8% of that in intact bitches. Bitches neutered after maturity have generally been considered to have the same risk as intact bitches. However, questions remain regarding the impact of ovariohysterectomy at the time of tumor excision. Questions also remain about the timing of such surgery relative to survival. In one study, dogs spayed <2 yr prior to tumor excision lived 45% longer than either intact dogs or those spayed >2 yr prior to tumor excision. The 2 posterior mammary glands are involved more often than the 3 anterior glands. Grossly, tumors appear as single or multiple nodules (1-25 cm) in 1 or more glands. The cut surface is usually lobulated, gray-tan, and firm, often with fluid-filled cysts. Mixed mammary tumors may contain grossly recognizable bone or cartilage on the cut surface.
More than 50% of canine mammary tumors are benign mixed tumors; a smaller percentage of malignant mixed tumors are seen. In the latter, epithelial or mesenchymal components, either singly or in combination, may produce metastases. Histologically, canine mammary gland tumors have been classified by the World Health Organization as carcinomas (with 6 types and additional subtypes), sarcomas (4 types), carcinosarcomas (mixed mammary tumors), or benign adenomas. This classification scheme is based on the extent of the tumor, involvement of lymph nodes, and presence of metastatic lesions (TNM system); it includes unclassified tumors and apparently benign dysplasias.