I posted back in January about my 10 year old boxer Jake having hemangiosarcoma. It has been a whirlwind month since then. We tried the metronomic therapy but Jake did not tolerate it well. He would lose his appetite and become lethargic, so we would stop the medicine. Once his appetite and energy picked up, we started him out with just one of the three medicinces. He did not tolerate it that way either. We took him back to the vet for another ultrasound and it showed that the cancer had spread to his spleen, liver and kidneys. All within one month. I was shocked that it happened so fast. Who knows if it was the medicine or the cancer spread making him feel lowsy. The vet put him on prednisone to get his appetite back up and to also help with some arthritis issues. He perked up for a few days but has slowly been going downhill since then. This past Friday I took him back to the vet and they found a small amount of blood in his abdomen. Now it is just a waiting game and it is killing the whole family. Just when I think it is time, he turns around and wags his tail and looks at me. I don't know if the look is telling me it's time or not. People keep telling me that I will know and I hope I do because I'm so confused, guilt ridden and stressed all at the same time. I have had Jake since he was six weeks old and he has been my companion and best friend through good times and bad. To let him go is killing me, but to possibly allow him to suffer is killing me also. The vet says he is not in pain, but is just feeling yucky, but how does anyone really know when they can't tell us. Please keep us in your thoughts.