what helped my dog
I have an English bulldog/boxer mix and well, she's just plain nuts! Her mama died in childbirth and she was bottlefed. She still sucks an old blanket when she gets stressed, or when she's going to sleep.
Everytime we went out, she had to be put into the crate, or confined to a room. She loved chewing remote controls, cell phones, etc. She would leave them in a pile in the middle of the floor. She also destroyed books and magazines.
She broke out in hives and other skin disorders, I was always at the vet with her. She was on anti biotics and a type of antihistamine.
A year ago, when she was a year old, I rescued a boxer. That was the best thing I ever did. She has calmed down, doesn't need to be in a crate, rarely chews anything, and will tell on her boxer brother if he does!
She is no longer on any medication whatsoever. She just needed a buddy, a brother. They love one another, but she's the alpha dog. Very patient with him, but puts him in his place when need be.
He is still in the crate when we leave for longer periods, but that is because he's so full of energy yet.
I suggest another dog. It's not that much more work, and they need the company, IMO.
Jane