We chose to do Chemo when Lola was diagnosed with Lymphoma not because we wanted to prolong her life in a way that would bring quantity over quality but because of what we learned through our research about the potential for Chemo to actually improve their quality of life and make them feel better. The way it was explained to us, in Veterinary Medicine they don't use the high doses as they would use in human medicine. In human medicine, the goal is to get rid of the Cancer and humans understand that they will feel sick from the Chemo with the goal of a cure. In veterinary medicine, the goal is remission and they don't use doses high enough to make the dog feel sick because the dog will not understand and obviously this wouldn't be fair to them. In what I read, Chemo can actually make them feel better because Cancer causes them pain, when you bring it into remission, it lessens the pain. The protocols used are generally very well tolerated by dogs. Prednisone is great for making them feel better but it will not do anything to bring the cancer into remission. It's simply to improve appetite and act as an anti-inflammatory. Prednisone is Cortisone which is the hormone that "pumps you up" so to speak. When we chose to do Chemo for Lola, she was ten years old and already dealing with Cushing's Disease. Although I don't know if it was the right decision as it didn't help in her case, I know that personally, I would have regretted not trying. However, as stated by other members, this is a very personal decision. I would just recommend reading as much as you can about it. I wish you all the best as you go through this difficult time.