It has made some difference. Tae's problem all along is she urinates and occasionally would poop when I am at work. I am unable to crate her b/c she panics and drools in the crate, but that's another story. ...she never did anything destructive whatsoever in the house.
Since going on Clomicalm, Tae stopped acting nervous when I prepared to leave for work. She would lick her lips, which is a sign of nervousness, but stopped. She would also stick to me like glue whenever I was home. Now, that's not abnormal for a Boxer, but she will now wander upstairs in the evenings and snooze on my bed for up to 3 hours. That's something she NEVER did before.
Tae continued to urinate in the house until two weeks ago (been on the med several months). I allowed her access to my bedroom (when I'm at work) and I think she spends most of the day sleeping on my bed. She hasn't gone potty in the house since. That's slightly complicating things b/c my assignment from the behaviorist is to set up a camera and videotape Tae after I leave for work. Going potty within 20-30 minutes after departure is what we are looking for to confirm sep anxiety, though it is not out of the question that she might just be anxious in general (will depend on when she goes potty per my behaviorist).
If you do start medication, keep in mind it will take 4-6 weeks to reach peak levels in the body. If no difference is seen at that point, you may need to up the dose. Tae started on 40 mg, but we upped it to 80 mg. It made her sleepy at first, but she adjusted--thank gosh--I felt guilty. It has taken me so long to do the videotape thing b/c I had knee surgery in early Nov and things were hectic for me in Nov and Dec as a result.
One alternative that my behaviorist recommended is DAP.
http://vetmedicine.about.com/cs/behavior/a/dogbehaviorprob.htm
http://www.biovets.com/behavior_modifiers_9_ctg.htm
She said it has worked for some dogs. I also know the local independent pet store will allow me to return it should I buy it and find it does not work. Just a thought...